GDC-0349 Flat

GDC-0349 FlatGDC 0349 is a potent and selective ATP competitive inhibitor of mTOR with Ki of 3. 8 nM, 790 fold inhibitory effect against PI3K? and other 266 kinases. Phase 1.

is an inhibitor of poly(ADP-ribose) polymerase with an IC50 of 3

the rate-limiting enzyme in de novo pterin synthesis

which directly binds and activates Smoothened

2 nM and IC50 values for the other class I PI3K isoforms (p110

2-adrenoceptor

and orally bioavailable mTOR inhibitor with IC50 of 16 nM

ML-IAP-BIR3

Greaseless Rotaflo® stopcocks allow smoother control and help eliminate titrating errors

CHIR-99021 HCl (CT99021) is hydrochloride of CHIR-99021

but not Stat5 phosphorylation

Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1

Approximate dish cover diameter and height is 100x10mm